Conference Portal, 2018 International Conference on Pure and Applied Science

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Evaluation of Oxidative Stress Status in Aged Human in relation to some Diseases
Esmail S. kakey, Amez A. Ismael

##manager.scheduler.building##: Presidency Building
##manager.scheduler.room##: Conference Hall
Date: 2018-04-24 11:00 AM – 11:20 AM
Last modified: 2018-08-16

Abstract


The current study included 60 aged persons (30 men’s and 30 women’s) at age ranges of (40-80) years and 30 young healthy persons (15 men and 15 women) as control groups. The samples were collected in the Educational Hospital of Shied Doctor Khalid in Koya city and nursing home in Erbil Governorate.  The blood sample was collected from subject and control persons. Then the serum separated and for biochemical analysis. The fully automated ELISA system was used for determination of oxidative and antioxidant parameters.  According to the results of the current study, the levels of oxidative stress parameter increased, and the levels of antioxidant parameters were decreased with aging. The data analysis showed significant (p<0.05) elevation of malondialdehyde (MDA) in both age groups of healthy and nonhealthy males and females, and its level is higher in smoker groups male than in nonsmoker one. And the level of protein carbonyl group was significantly (p<0.05) in both age groups of nonhealthy and healthy males and females, and its level is higher in smoker aged group men than in nonsmoker groups. The result revealed that the level of superoxide dismutase (SOD) was significantly (p<0.05) decreased in both aged group of healthy and nonhealthy males and females and the level of superoxide dismutase is lower in smoker aged group men than in nonsmoker one. Also, the level of total antioxidant capacity is lower in smoker aged men than in nonsmoker one.

 

Published 01 August 2018

DOI: 10.14500/icpas2018.bph28

http://dx.doi.org/10.14500/icpas2018.bph28


Keywords


Age-related disease; Aging; Oxidative stress

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